Central ventilatory effects of thyrotropin-releasing hormone in the conscious rat.

The Therapeutic Effect of Thyrotropin Releasing Hormone in Amyotrophic Sclerosis

Although the issue has not yet been fully resolved, there is reason to believe that TRI-I may have a trophic effect on the normal motoneuron and may transien­ tly improve the neurologic deficit in ALS. Since ALS is not a simple TRI-I deficiency disease, this improvement probably occurs via a secondary mecha -nism-possibly another neurotransmitter. It is uncertain at this time whether this effec...

Elucidation of the central regulation of the hypophysiotropic corticotropin-releasing hormone- and thyrotropin-releasing hormone-synthesizing neurons in the rat Ph.D. Thesis

TRH microdialysis into the RTN of the conscious rat increases breathing, metabolism, and temperature.

Thyrotropin-releasing hormone (TRH) injected into the retrotrapezoid nucleus (RTN) of anesthetized rats produces a large, prolonged stimulation of ventilatory output (C. L. Cream, A. Li, and E. E. Nattie. J. Appl. Physiol. 83: 792-799, 1997). Here we inject or dialyze TRH into the RTN of conscious rats. In 6 of 17 injections (200 nl, 3.1 +/- 1.7 mM), ventilation (VE) increased 31% by 10 min, wi...

Effect of Aerobic Exercise on Thyroid Hormones and Quality of Life in Obese Postmenopausal Women

ABSTRACT            Background and objectives: Studies have shown that exercise can affect hormone secretion and some metabolic and endocrine functions. The aim of this study was to assess the effect of eight weeks of aerobic training on thyroid hormones and quality of life in obese postmenopausal women.            Methods: In this semi-experimental study, 21 obese (body mass index >30 Kg/m2)...

Antisense inhibition of thyrotropin-releasing hormone reduces arterial blood pressure in spontaneously hypertensive rats.

Thyrotropin-releasing hormone (TRH) plays an important role in central cardiovascular regulation. Recently, we described that the TRH precursor gene overexpression induces hypertension in the normal rat. In addition, we published that spontaneously hypertensive rats (SHR) have central extrahypothalamic TRH hyperactivity with increased TRH synthesis and release and an elevated TRH receptor numbe...